Happy Rhodes covers David Bowie's Space Oddity. Her voice starts out with a low eerie quality befitting the song and then begins to soar at the 51 second mark. The backup singer is Kelly Bird (great voice also) and the guitarist is Kevin Bartlet. In my opinion this is the finest cover ever done of this classic song.
If you liked this cover, check out this post for some of Happy's original work.
And for you purists, here is the original sung by David Bowie.